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    Distillation-Based
    Distillation-Based Pure Media Systems

    Distillation-based PS and WFI generation

    wfi-pharmaceutical

    Syntegon offers a flexible, turn-key solution for the distillation-based (i.e. thermal) generation of pharmaceutical-grade pure steam (PS) and water for injection (WFI). Whether a single, dual, or triple mode solution, our robust technology is based on natural circulation distillation. All that is required for operation is the supply of heating steam to the first column; all other modules are heated in an energy-efficient manner utilizing the heat generated during the preceding process stage. The sterile steam is condensed to high-purity water of WFI quality at every subsequent process stage. Our proven approach meaningfully reduces the associated footprint and energy consumption.  

    Product brochures
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    Key benefits

    Reliability
    The robust distillation-based technology is highly reliable. You can count on both the water’s quality and the stability of its supply.
    Serviceability
    The design is highly hygienic and accessible. Routine maintenance is quick and easy, minimizing downtime.
    Efficiency
    The compact, skidded system is an energy-efficient thermal system. Our technology meaningfully reduces operating costs.

    Features of our distillation-based pure media systems

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    Configuration flexibility

    Syntegon’s distillation-based pure media systems are robust, proven solutions that can be easily and quickly configured to meet your specific requirements. All configuration options are pre-tested and readily available. With a wide production range of both WFI and PS, the skidded systems are suitable for clinical and commercial manufacturing facilities alike.

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    Process efficiency and robustness

    Syntegon’s distillation technology offers energy-efficient GMP generation of WFI and PS with only 3-5% blow-down. And with an all-SS construction, low mechanical stress on the heat exchanger, as well as a low scaling tendency with a bell-type separation system instead of a demister, the system is superbly robust.

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    Footprint and serviceability

    Our distillation systems feature a pre-fabricated, skidded drop-in configuration that can be rapidly delivered, installed, qualified, and put into operation. And whether delivered as a stand-alone solution or integrated system, the system configuration is always highly hygienic and accessible, making maintenance quick and easy.

    Pure steam (PS) and water for injection (WFI) are essential utilities in pharmaceutical manufacturing that have long been produced with distillation-based generation systems. Syntegon’s distillation technology offers energy-efficient GMP generation of WFI and PS with only 3-5% blow-down. With an all-SS construction, low mechanical stress on the heat exchanger, as well as a low scaling tendency with a bell-type separation system instead of a demister, our systems are superbly robust. And with a patented droplet separation system to remove any residual pyrogens, the quality of the generated PS and WFI is assured to be conforming at all times.

    Benefits
    • Reliable supply of pharmaceutical-grade PS and WFI
    • Configuration flexibility to meet customer-specific requirements
    • Energy-efficient distillation technology with minimal blow-down
    • Superb robustness with low mechanical stress and scaling tendency
    • Patented droplet removal system for assured residual pyrogen removal

    Use case scenarions

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    Pure steam
    Single column unit for the generation of PS with low mechanical stress on the heat exchanger with integrity check without dismantling
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    Pure steam and water for injection
    Single, dual, or triple mode distillation units for the generation of WFI and/or PS with a low scaling tendency
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    Storage and distribution
    Comprehensive storage and distribution systems for PW and WFI with continuous monitoring of all quality-relevant attributes.
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    Recirculation loops

    Distribution loops with recirculation lines with point-of-use management and sanitization.

    Technical data of distillation-based pure media systems

    only  
    %
    blow-down
    PS up to  
    kg/hr
    WFI up to  
    l/hr
    storage and distribution up to  
    l/hr
    Technical data 

     

    PS

    WFI

    Storage and Distribution

    Container

    up to 500-5,000 kg/hr

    		   up to 500-12,000 l/hr up to 38,500 l/hr

    Processing range container
    • thermal degassing
    • membrane degassing

     
    • thermal degassing
    • membrane degassing
    • dual mode (WFI or PS)
    • double pump station
    • steam sterilization (SIP)
    • UV lamp
    • TOC measurement
    • cold storage with sanitization 85C
    • hot storage with sanitization 121C
    • cold storage with ozone

     

     

     
    Configure-to-order selection

    We offer the right pretreatment, generation, and storage and distribution solutions for every water quality. Larger and intermediate sizes are also available upon request, as well as a wide range of other modular options that can be integrated into customer-specific systems.

    *standard configure-to-order systems; custom solutions with higher output are also available

    Service Agreements
    Service Agreements

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    Digital Solutions
    Digital Solutions

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    Parts
    Parts

    スペアパーツの詳細については、こちらをご覧ください。

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    Maintenance
    Maintenance

    メンテナンスの詳細については、こちらをご覧ください。

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    Technical Support
    Technical Support

    リモートサービスの詳細については、こちらをご覧ください。

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    Modernizations
    Modernizations

    最新化（改造）の詳細については、こちらをご覧ください。

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    Training
    Training

    トレーニングの詳細については、こちらをご覧ください。

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    Expert Services
    Expert Services

    コンサルティング関連サービスの詳細については、こちらをご覧ください。

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    Why choose a Syntegon distillation-based pure media system?

    distillation-unit

    We have the right technology and experience

    The Syntegon subsidiary Pharmatec has been supplying pure media systems to the global pharmaceutical industry for 30 years. All over the world, our solutions provide everything that is required for a seamlessly integrated system infrastructure – from hot and cold generators to storage and distribution systems; from pre-configured units to highly customized solutions. Regardless of the application, our systems provide a seamless process from generation to distribution at the point of use, including the associated CIP systems.

     
    years of experience
     
    installed systems
     
    unique customers
     
    countries

    Downloads

    Pure Media Systems Brochure
    Pure Media Systems Brochure

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    Save energy and water
    Save energy and water

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    関連情報

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